THE MAO LAB

Research in Dr. Xiaobo Mao's laboratory focuses on two core topics: (1) the roles of prion-like proteins and strains in neurodegenerative disorders, including spreading pathways, molecular mechanisms of cell-to-cell transmission, neurotoxicity, and neuroinflammation; (2) the therapeutic developments.=

Xiaobo Mao, PhD

TITLE

Associate Professor of Neurology

EDUCATION

PhD - National Center for Nanoscience and Technology, China

RESEARCH FOCUS

Cell and Protein Biology, Biophysics

RESEARCH TEAM

  • Ning Wang, PhD

    POSTDOCTORAL FELLOW

  • Haiqing Liu, PhD

    POSTDOCTORAL FELLOW

  • Kundlik Gadhave, PhD

    POSTDOCTORAL FELLOW

  • Deok Jeong, PhD

    POSTDOCTORAL FELLOW

  • Xiuli Yang, MD, PhD

    POSTDOCTORAL FELLOW

  • Shuya Li, PhD

    POSTDOCTORAL FELLOW

  • Junkai Hu, PhD

    POSTDOCTORAL FELLOW

  • Shiyu Su

    PhD Candidate

SELECTED PUBLICATIONS

  • Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Goncalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science. 2016 Sep 30;353(6307).

  • Kam TI#, Mao X#, Park H# (# equal contribution), Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM and Dawson VL. Poly (ADP-ribose) Drives Pathologic α-Synuclein Neurodegeneration in Parkinson’s Disease. Science. 2018;362(6414). doi: 10.1126/science.aat8407.

  • Mao X, Guo Y, Luo Y, Niu L, Liu L, Ma X, Wang H, Yang Y, Wei G, Wang C. Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy. J Am Chem Soc. 2013 Feb 13;135(6):2181-7. 

  • Liu YQ, Mao YY (co-first), Xu EQ, Jia HM, Zhang S, Dawson VL, Dawson TM, Li YM*, Zheng Z*, He WW*, Mao X*. Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission in Parkinson’s Disease. Nano Today. 2021, 36, 101027

  • Zhang SN, Liu YQ, Jia CY, Lim YJ (co-first), Feng GQ, Xu EQ, Kimura Y, Long HF, Tao YQ, Zhao CY, Wang CC, Liu ZY, Hu JJ, Ma MR, Liu ZJ, Jiang L, Li D, Wang RX, Dawson VL, Dawson TM*, Li YM*, Mao X*, Liu C*. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proc Natl Acad Sci. USA. 2021;118(26): e2011196118

PATENTS

  • A detection method for the relative adsorption constant of dye, antibody, drug and pro-drug molecules on peptides.
    Patent # WO2011060598A1 & CN102062718 | 

  • Therapeutic Uses of LAG3 the α-Synuclein Transmission Receptor.
    Patent # WO2018039147A1, PCT/US2017/047878 | 

  • Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission in Parkinson’s Disease
    Patent # C16214 |