Poly(ADP-Ribose) Polymerase-1 Triggers AIF-Mediated Neuronal Death

Written By Dawson Lab

Science, 2002

A foundational discovery demonstrating that overactivation of PARP-1 leads to caspase-independent neuronal death via apoptosis-inducing factor (AIF). This work established the basis for defining parthanatos as a distinct cell death program.

Dawson Lab https://www.thedawsonlab.org
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A Nuclease that Mediates PARP-1–Induced Cell Death