A Nuclease that Mediates PARP-1–Induced Cell Death

Written By Dawson Lab

Science, 2016

This landmark paper identifies MIF as the nuclease that fragments DNA during parthanatos. It provides a missing piece of the puzzle and opens the door to therapeutic strategies aimed at preventing parthanatos-driven neuronal loss.

Dawson Lab https://www.thedawsonlab.org
Previous

Parthanatos: Mechanisms, Modulation, and Therapeutic Prospects
Next

Poly(ADP-Ribose) Polymerase-1 Triggers AIF-Mediated Neuronal Death